中药药剂学实验室

教学实验中心中药药剂学实验室成立于2003年，位于4号楼四楼五楼，主要为中药学专业本科课程中药药剂学、药学综合性实验、药剂综合性实验等提供实验教学服务。根据实验教学需要，本实验室设有综合性实验室4间（其中一间为大学生科创及本科毕业设计开放性实验室）、旋转蒸发仪器室、大学生科学创新仪器室、中药药剂学仪器室等，总占地面积1000M2。现有专职技术人员共8人，其中研究员1人，高级实验师1人，实验师6人，其中硕士以上学历者6人。在完成实验准备工作的基础上，我们还提供实验课程主讲与带教、虚拟实验课程开发、实验室安全管理、仪器的使用与维护、实验室与实验技术SOP、实验课程开发等实验教学服务工作。

一、实验教学 

中药药剂学实验室目前主要承担中药学、药学等专业，涉及中药专业本科、夜大的实验教学准备工作和部分实验课程的主讲及带教任务。教学内容涵盖了中药及药学类专业11门实验课程，主要有中药学专业技能训练、药剂综合性实验、中药化学实验、中药药剂学实验等课程的102个实验项目。

二、教学实验的准备工作

实验技术人员负责课程中实验试剂、药材、药品、玻璃仪器的清点、采购、预实验、课前准备及课后回收等工作。

三、实验带教工作

根据实验课程的需要和实验技术人员实验技能特长，参与了《天然大分子化学》、《PRACTICAL CHEMISTRY IV》等课程的仪器操作带教工作。

四、实验课程主讲

目前，科室部分实验技术人员已参与《中药新药药学研究技术与方法》、《中药学专业实验技能训练》等课程的实验主讲工作，展现了实验技术人员在实验技术上的优势。

五、《中药学专业技能操作训练》课程

《中药学专业实验技能训练》 是专门针对我校中药学专业学生的实验技能培训和考核而设置的一门必修课，是《中药学基本实验技能训练》课程的延续。该课程设立多模块小班化教学。现已设立中药压片技术、中药炮制技术、中药制丸技术、高效液相技术、薄层色谱技术、中药鉴定技术、动物实验操作技术、中药真伪鉴别技术等八个模块。

六、仪器的管理与维护

中药学实验室现有原子吸光光度计、中药压片机、中药制丸机、中药滴丸机、中药片剂四用仪、旋转蒸发仪等仪器，实验技术人员负责机器的日常维护工作。

七、大学生创新活动与实验室开放

近三年来，本实验室多位老师参与了本科生毕业实习的带教工作和大学生创新活动的指导工作，并提供多个可供学生自主学习和实验的平台。近三年团队共指导大学生科创项目13项。并先后指导学生参加全国各类大学生创新创业和实验技能竞赛获奖15项，包括全国“挑战杯”二等奖1项、上海市“挑战杯”特等奖1项、世界大学生药学/中药学创新创业大赛国际组特等奖1项、全国药学/中药学创新创业大赛特等奖2项及全国药学/中药学大学生实验技能大赛获特等奖6项等，并且指导团队还注重自身教学能力的培养，更好地指导大学生项目，教学成果获国家级虚拟仿真项目1项、上海教学成果奖一等奖1项。教师获全国药学/中药学实验教学改革大赛特等奖和一等奖各1项。

指导大学生创新创业及全国技能大赛获奖

· 第十六届上海市“挑战杯”大学生课外学术科技作品竞赛 特等奖·

· 第十六届全国“挑战杯”大学生课外学术科技作品竞赛 二等奖 

· 第二届医药院校药学/中药学世界大学生创新创业大赛 国际组特等奖

· 第一届医药院校药学/中药学世界大学生创新创业大赛 特等奖

· 第八届“神农杯”大学生课外学术科技作品竞赛 一等奖

· 第六届全国医药院校药学/中药学专业大学生实验技能竞赛 特等奖

· 第六届全国医药院校药学/中药学专业大学生实验技能竞赛 一等奖

· 第五届全国医药院校药学/中药学专业大学生实验技能竞赛 特等奖 

教师指导大学生科创情况：

八、近三年教师指导本科生发表论文、专利情况

指导学生发表论文

[1] A Ratiometric and Colorimetric Hemicyanine Fluorescent Probe for Detection of SO2 Derivatives and Its Applications in Bioimaging [J]., Molecules 2019, 24, 4011（学生第一作者）

[2] Synthesis and Biological Evaluation of Novel Alkyl Amine Substituted Icariside II Derivatives as Potential Anticancer Agents [J]. Molecules 2018, 23, 2146 （学生第一作者）

[3] Chemical Fingerprinting and Quantification of Chinese Cinnamomi Cortex by Ultra High Performance Liquid Chromatography Coupled with Chemometrics Methods [J]. Molecules 2018, 23, 2214（学生第一作者）

[4] 不同树龄肉桂树皮挥发油及桂皮醛含量比较 [J]. 广西林业科学, 2018, 47(03):112-115.（学生第一作者）

[5] 正交试验法优选左金浓缩丸成型工艺 [J]. 中国药师, 2018,3(21):389-392. （学生第一作者）

[6] 基于HPLC指纹图谱及聚类分析评价市售阿胶的质量[J]. 上海中医药大学学报, 2017(06):95-100. （学生第一作者）

[7] 广藿香超声辅助提取工艺考察[J]. 世界科学技术-中医药现代化, 2018, 20(09):207-211.（学生第一作者）

[8] 肉桂的化学成分、药理作用及综合应用研究进展[J]. 中国药房, 2018, 29(18):138-141.（学生第一作者）

[9] A Fluorescent Coumarin-Based Probe for the Fast Detection of Cysteine with Live Cell Application, Molecules 2017, 22, 1618. (学生第三-六作者)·

[10] Yinchenhao Decoction Ameliorates Alpha-naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters, Frontiers in Pharmacology. doi: 10.3389/fphar. 2018.00510 (学生第四作者)

[11] A near-infrared Nile Red fluorescence probe for discrimination of biothiols by dual-channel response and its bioimaging applications in living cells and animals, Analyst：DOI: 10.1039/C9AN00280D (学生第五作者)

[12] A simple pyrene-hemicyanine fluorescent probe for colorimetric and ratiometric detection of SO2, derivatives in the mitochondria of living cells and zebrafish in vivo，Sensors & Actuators B Chemical, 2018. 2018: 328–337 (学生第六作者)

[13] Design, synthesis and evaluation of novel ferulic acid derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease, Bioorganic Chemistry, doi.org/10.1016/j.bioorg.2019.103413 (学生第三、六、七作者)

[14] Design, synthesis and biological activity of novel donepezil deri- vatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors, Eur J Med Chem.2017.133:184-196 (学生第七作者)

[15] Icariside II induces cell cycle arrest and differentiation via TLR8/MyD88/p38 pathway in acute myeloid leukemia cells. Eur J Pharmacol. 2019 Mar 5;846:12-22 (学生第八作者)

[16] HPLC法结合统计学方法研究复方丹参片中皂苷类成分[J]. 辽宁中医杂志, 2019, 46(01):126-129.（学生第二作者）

[17] 竹叶提取工艺的综合性评价[J]. 中国实验方剂学杂志, 2018(17). （学生第二、三作者）

[18] 生物酶解技术对中药知母抗真菌作用的影响[J]. 上海中医药大学学报, 2019(05):67-72.（学生第二、四作者）

[19] 芩麻颗粒前处理工艺的优化[J]. 中成药. （学生第五作者）

指导学生申请专利

· 一种含挥发油包合物的温灸穴位贴. (授权号：ZL 201610130183.8，学生第一发明人)

· 一种二氧化硫快速检测荧光试剂套装. (授权号：ZL201921681676.6，已授权，学生第二、三、四发明人)

` 一种用于二氧化硫/亚硫酸（氢）盐检测的荧光探针及其制备方法和应用。(申请号：201910389203.7，学生第二、五、六发明人)

九、团队成果

1. 教学课题申报 

2. 教学文章发表： 

教师教学获奖

4. 教材编写 

实验室技术人员发挥实验技术特长积极参与教材编写。作为编委及参编人员近年来参与编写《中药新药药学研究技术与方法》、《中药学专业实验技能训练》、《中药化学实验》等多本教材及实验讲义

十、科研成果

1. 科研项目

1) 重大新药创制科技重大专项2018年度课题:中医临床大数据分析的中药新药研发及其关键技术研究, 项目编号：2018ZX09201008-002，2018年1 月-2020年12月

2) 上海市生物医药领域科技支撑项目，古代经方甘姜苓术汤的复方制剂研究，19401901800，张彤，主持

3) 国家重大专项，重大新药创制，基于中医典籍的经典名方研发，2017ZX09201010-014-014，张彤，合作单位负责人

4) 国自然面上项目，基于胆红素代谢酶和转运体研究何首乌诱导高胆红素血症的物质基础及预测方法，81872981,丁越，主持

5) 上海市优秀学术带头人，基于体内代谢的清热利胆类中药的药效物质基础研究，18XD1403700，张彤，主持

6) 上海市青年科技英才扬帆计划项目，知母皂苷AIII的制备及其双载药纳米脂质体研究，19YF1449000路璐，主持

7) 上海市人才发展基金，基于胆红素代谢酶和转运体研究中药诱导高胆红素血症的物质基础及预测方法，2018105丁越，主持

8) 上海卫计委青年优秀人才项目，中药诱导胆红素升高的作用机制及系统预测方法研究，2017YQ072，丁越，主持

9) 国自然青年项目，基于“汤液相态-物质成分-生物效应”的相关性研究“去滓再煎”对半夏泻心汤的药性调和作用，82003962，浦益琼，主持

10)国自然青年项目，硫化汞在人体胃肠道内的甲基化及其健康风险研究，41907365，夏振江，主持

2.科研论文：

[1] YaNan Kang#, Lu Lu#, JinShuai Lan ,Yue Ding*, Jing Yang, Yong Zhang, Yuan Zhao, Tong Zhang*, Rodney J.Y. 2018, Redox-responsive polymeric micelles formed by conjugating gambogic acid with bioreducible poly(amido amine)s for the co-delivery of docetaxel and MMP-9 shRNA[J].Acta Biomaterialia(IF 6.383).68: 137-153.(被引20次)

[2] JinShuai Lan# , RuiFeng Zeng# , Yue Ding* , Yong Zhang , Tong Zhang* , Tong Wu .2018, A simple pyrene–hemicyanine fluorescent probe for colorimetric and ratiometric detection of SO2 derivatives in the mitochondria of living cells and zebrafish in vivo[J].Sensors and Actuators B(IF 5.667).268: 328-337.(被引19次)

[3] Han Han# , Lili Xu # , KaiXiong  , Tong Zhang* , ZhengTao Wang *.2018,Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha Naphthylisothiocyanate Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures[J].Cell Physiol Biochem(IF 5.5 ). 49: 1304-1319.(被引4次)

[4] Rong Yang#, ZhuoNa Wu, YiQiong Pu, Tong Zhang*, BingWang*. 2018.Fast and non–derivative method based on high–performance liquid chromatography–charged aerosol detection for the determination of fatty acids from\r, agastache rugosa\r, (fisch. et mey.) o. ktze. seeds[J]. Natural Product Research(IF 1.928).2018:1-6.(被引0次)

[5] Yue Zhang# , XiTong Zhang , Q i Zhang , Bing Wang* , Tong Zhang*.2018, Formulation development and Evaluation of gastroretentive floating beads with Brucea javanica oil using ionotropic gelation technology[J].Chin. J. Nat. Med(IF 1.991).16: 293-301.(被引3次)

[6] Yue Zhang#, XiTong Zhang, Qi Zhang, Bing Wang*, Tong Zhang*.  Formulation development and Evaluation of gastroretentive floating beads with Brucea javanica oil using ionotropic gelation technology[J]. Chin. J. Nat. Med(IF 1.667).16: 293-301.(被引3次)

[7] Kai Xiong# , ZhengCai Ju , Tong Zhang* , ZhengTao Wang , Han Han*. 2018, Metabolic profiles and pharmacokinetics of picroside I in rats by liquid chromatography combined with electrospray ionization tandem mass spectrometry[J].Journal of Chromatography B(IF 2.441).1095: 157-165.(被引4次)

[8] YiShun Yang# , Yue Ding , Tong Zhang*. 2018,Biotransformation of geniposide into genipin by immobilized Trichoderma reesei and conformational study of genipin[J].Biomed Research International(IF 2.583). 2018: 1-10.(被引1次)

[9] Yue Zhang# , LiYing Zhang , Qi Zhang , XiTong Zhang , Tong Zhang* , Bing Wang*.2018,Enhanced gastric therapeutic effects of Brucea javanica oil and its gastroretentive drug delivery system compared to commerical products in pharamacokinetics study[J].Drug Design, Development and Therapy(IF 2.935). 12: 535-544.(被引4次)

[10] ShiYu Zong# , YiQiong Pu# , SuYan Li , BenLiang Xu , Yong Zhang , Tong Zhang* , Bing Wang* .2018.Beneficial anti-inflammatory effect of paeonol self- microemulsion-loaded colon-specific capsules on experimental ulcerative colitis rats[J].Artificial Cells, Nanomedicine, and Biotechnology(IF  3.026).2018:1-12.(被引11次)

[11] Zhang, Q (Zhang, Qi)# ; Huang, X (Huang, Xing)3 ; Pu, YQ (Pu, Yiqiong) ; Yi, YX (Yi, Yaxiong) ; Zhang, T (Zhang, Tong)* ; Wang, B (Wang, Bing)*.2018.pH-sensitive and biocompatible quercetinloaded GO–PEA–HA carrier improved antitumour efficiency and specificity[J]Artificial Cells, Nanomedicine, and Biotechnology（IF 3.026）.2018: 1-10.(被引8次)

[12] XiaoTian Zhang# , Yue Ding# , Ping Kang , XinYu Zhang* , Tong Zhang*.2018.Forsythoside A Modulates Zymosan-Induced Peritonitis in Mice[J].Molecules(IF 3.098).2018, 23: 593-602.(被引5次)

[13] Tong Wu#, Ting Li#,YaNan Kang, Li Liu, XiMan Wang, JinShuai Lan*, Y ueDing*, Tong Zhang.2018,Synthesis and Biological Evaluation of Novel Alkyl Amine Substituted Icariside II Derivatives as Potential Anticancer Agents[J].molecules(IF 3.098). 23: 2146-2168.(被引3次)

[14] YiLin Guo# , ShiuY Zong , YiQiong Pu , BenLiang Xu , Tong Zhang* , Bing Wang*.2018,Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease[J].Molecules(IF 3.098). 23: 1622-1636.(被引6次)

[15] YaXiong Yi# , Yue Ding*, Yong Zhang , NingHui Ma , Feng Shi , Pang Kang , ZhenZ henCai , Tong Zhang*. 2018, Yinchenhao Decoction Ameliorates Alpha- naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters[J]. Frontiers in Pharmacology(IF  3.831).9: 510-538.(被引4次)

[16] Ming Peng# , YaX Yi# , Tong Zhang , Yue Ding* , Jian Le.2018.Stereoisomers of saponins in panax notoginseng (sanqi): a review[J].Frontiers in Pharmacology(IF  3.831).2018, 9: 188-205.(被引16次)

[17] JinShuai Lan# , Yun Liu# , JianWei Hou , Jing Yang , XinYu Zhang , Yuan Zhao ,  SaiSai Xie *, Yue Ding* , Tong Zhang.2018.Design, synthesis and evaluation of resveratrol-indazole hybrids as novel monoamine oxidases inhibitors with amyloid-b aggregation inhibition[J] .Bioorganic Chemistry(IF 3.929 ). 2018, 76: 130–139(被引10次)

[18] Lu Lu#, Yue Ding* , Yong Zhang ,  Ho,RJY , Yuan Zhao , Tong Zhang*, ChunRong Guo. 2018, Antibody-modified liposomes for tumor- targeting delivery of timosaponin AIII[J].International Journal of Nanomedicine(IF 4.37).2018,13: 1927-1944. (被引11次)

[19] YiShun Yang#, Yuan Zhao,JinShuai Lan, YaNan Kang, Tong Zhang*, Yue Ding*, XinYu Zhang, Lu Lu. 2018, Reduction-sensitive CD44 receptor-targeted hyaluronic acid derivative micelles for doxorubicin delivery[J].International Journal of Nanomedicine(IF 4.37).2018,13: 4361-4378.(被引9次)

[20] NingHui Ma# , Yue Ding# , Yong Zhang* , Tong Zhang *, YaXiong Yi , Bing Wang. 2018,Chemical Fingerprinting and Quantification of Chinese Cinnamomi Cortex by Ultra High Performance Liquid Chromatography Coupled with Chemometrics Methods[J].  Molecules(IF 3.098).  2018,23: 2214-2229. (被引1次)

[21] Lan, JS (Lan, Jinshuai)# ; Guo, J (Guo, Jing)# ; Jiang, XY (Jiang, Xiaoyi) ; Chen, Y (Chen, Yi) ; Hu, ZH (Hu, Zhenghao) ; Que, YF (Que, Yuanfang) ; Li, HX (Li, Hongxin); Gu, JY (Gu, Jingyi); Ho, RJY (Ho, Rodney J. Y.) ; Zeng, RF (Zeng, Ruifeng) ; Ding, Y (Ding, Yue)* ; Zhang, T (Zhang, Tong)*.2019.A new dicyanoisophorone-based ratiometric and colorimetric near-infrared fluorescent probe for specifically detecting hypochlorite and its bioimaging on a model of acute inflammation. Analytica Chimica Acta(IF 5.256 )Analytica Chimica Acta 1094 (2020) 70-79.(被引3次)

[22] Lan, JS (Lan, Jin-Shuai) #; Zeng, RF (Zeng, Rui-Feng) ; Liu, Y (Liu, Yun)#; Xiang, YW (Xiang, Yan-Wei); Jiang, XY (Jiang, Xiao-yi); Liu, L (Liu, Li); Xie, SS (Xie, Sai-Sai) ; Ding, Y (Ding, Yue* ; Zhang, T (Zhang, Tong)*. 2019,A near-infrared Nile red fluorescent probe for the discrimination of biothiols by dual-channel response and its bioimaging applications in living cells and animals. Analyst. (IF 4.019)2019, 144:3676-3684.(被引4次)

[23] Jing Yang# , JinShuai Lan , HongZhi Du , XiaoLing Zhang , AiYun Li , XinYu Zhang , Yun Liu , JieYi Zhang , ChaoChao Zhang , Yue Ding* , Tong Zhang*.2019.Icariside II induces cell cycle arrest and differentiation via TLR8/MyD88/p38 pathway in acute myeloid leukemia cells[J].European Journal of Pharmacology(IF 3.04).DOI:10.1016/j.ejphar.2019.846:12-22(被引1次)

[24] Yi Zhang# , Yue Ding# , Tong Zhang , Xiaoyi Jiang, Yaxiong Yi, Lijuan Zhang, Yi Chen, Ting Li*, Ping Kang , Juanjuan Tian. 2019,Quantitative Analysis of Twelve Active Components Combined With Chromatographic Fingerprint for Comprehensive Evaluation of Qinma Prescription by Ultra-Performance Liquid Chromatography Coupled With Diode Array Detection. Journal of Chromatographic Science(IF 1.216), 2019, 57(9): 855-865. (被引0次)

[25] Yang, R (Yang, Rong)# ; Wu, ZN (Wu, Zhuona)# ; Pu, YQ (Pu, Yiqiong)# ; Zhang, T (Zhang, Tong)* ; Wang, B (Wang, Bing)*.2019,Fast and non-derivative method based on high-performance liquid chromatography-charged aerosol detection for the determination of fatty acids from Agastache rugosa (Fisch. et Mey.) O. Ktze. seeds.NATURAL PRODUCT RESEARCH(IF 1.999). 33(13 ): 1969-1974(被引0次)

[26] Shi, MG (Shi, Mengge)# ; Gao, TT (Gao, Tingting) ; Zhang, T (Zhang, Tong)*; Han, H (Han, Han)*,2019,Characterization of curcumin metabolites in rats by ultra-high-performance liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.RAPID COMMUNICATIONS IN MASS SPECTROMETRY（IF 2.045).33(13): 1114-1121(被引4次)

[27] Gu, SH (Gu, Sihao)# ; Li, L (Li, Ling)#; Huang, H (Huang, Hai); Wang, B (Wang, Bing)* ; Zhang, T (Zhang, Tong)*,2019,Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods.MOLECULES(IF 3.06), 24 (16).(被引3次)

[28] Jin, MY (Jin, Minyi)# ; Zhang, T (Zhang, Tong)* ; Ding, Y (Ding, Yue); Huang, TP (Huang, Tingpeng) ; Cai, ZZ (Cai, Zhenzhen)*.2019,Enhancement effect of geniposide on solubility and intestinal absorption of baicalin.PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES(IF 0.596).32 ( 5 ): 1933-1940.(被引0次)

[29] Zhang, Y (Zhang, Yi)# ; Ding, Y (Ding, Yue)# ; Zhang, T (Zhang, Tong) ; Jiang, XY (Jiang, Xiaoyi); Yi, YX (Yi, Yaxiong); Zhang, LJ (Zhang, Lijuan) ; Chen, Y (Chen, Yi) ; Li, T (Li, Ting)* ; Kang, P (Kang, Ping) ; Tian, JJ (Tian, Juanjuan).2019,Quantitative Analysis of Twelve Active Components Combined With Chromatographic Fingerprint for Comprehensive Evaluation of Qinma Prescription by Ultra-Performance Liquid Chromatography Coupled With Diode Array Detection.JOURNAL OF CHROMATOGRAPHIC SCIENCE(IF 1.216 ). 57 ( 9): 855-865.(被引0次)

[30] Zhang, LY (Zhang, Liying)# ; Xu, CC (Xu, Congcong) ; Mao, JJ (Mao, Jingjing) ; Wang, WW (Wang, Weiwei); Han, H (Han, Han) ; Pu, YQ (Pu, Yiqiong)* ; Zhang, T (Zhang, Tong)*.2019,Formulation and Characterization of Novel Dry Suspension and Dry Emulsion of 20(S)-Protopanaxadiol.AAPS PHARMSCITECH(IF 2.608). 20( 7).(被引2次)

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